منابع مشابه
Diabetogenic effect of cyclosporin.
A young woman given a renal allograft for polycystic kidney disease developed insulin dependent diabetes mellitus 25 days after transplantation. There was no family history of diabetes, plasma glucose concentrations had been normal at presentation and on five subsequent occasions, and at no time were islet cell antibodies detectable. Plasma C peptide concentrations, however, were greatly suppre...
متن کاملDiabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells.
Treatment of patients after organ transplantation with the immunosuppressive drug cyclosporin A (CsA) is often accompanied by impaired glucose tolerance, thus promoting the development of diabetes mellitus. In the present article we show that 2 to 5 microM CsA diminishes glucose-induced insulin secretion of isolated mouse pancreatic islets in vitro by inhibiting glucose-stimulated oscillations ...
متن کاملThe Diabetogenic Effect of Dehydroascorbic
The chemical properties of these two substances are strikingly similar. Both compounds are irreversibly decomposed under biological conditions. Alloxan has a half life of 1 minute (1) and dehydroascorbic acid has a half life of a few minutes (2). Alloxan is readily reduced to dialuric acid (3) with which it forms alloxantin (3). Dehydroascorbic acid is readily reduced to ascorbic acid (4) and a...
متن کاملEffect of Cyclosporin on Hepatic Regeneration.
THE CAPACITY of the liver to regenerate after orthotopic liver transplantation is a critical process that is dependent on numerous factors. The effect of drugs, especially immunosuppressive agents, administered during the period when the transplanted liver is most vulnerable is clearly important. We describe preliminary studies examining the effect of cyclosporin A (CsA) on hepatic regeneration...
متن کاملeffect of oral presentation on development of l2 learners grammar
this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...
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ژورنال
عنوان ژورنال: BMJ
سال: 1987
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.294.6569.401